TNF, or Tumor Necrosis Factor, is a specific chemical in the body that may cause inflammation associated with Crohn's disease. A new generation of medications that act against TNF are now available for the treatment of resistant Crohn's disease. They include infliximab or Remicade . Recent research has shown that some of these drugs may cause an increased risk of cancer, especially in children and teenagers. Talk with your healthcare provider about the risks and benefits of these medications.