Botox injections are another treatment option. Botox is the same product that helps smooth facial wrinkles. It does this by paralyzing certain muscles. Doctors have discovered that Botox injections are also an effective way to treat severe hyperhidrosis. It works by blocking the nerves that control the sweat glands. Botox injections have a temporary effect lasting up to four months. To control hyperhidrosis, patients will need Botox injections into their palms about every 4 months. This procedure is tolerable but is not the most comfortable.