Prescription oral medications used to treat acne include: Antibiotics, such as tetracycline (minocycline, doxycycline) or a macrolide. Oral contraceptives that combine estrogen and progesterone, such as Ortho Tri-Cyclen<SUP> </SUP> or Yaz<SUP> </SUP>. Spironolactone (Aldactone<SUP> </SUP>).